Best Betaine (TMG) Supplements 2026: Cost per Effective Dose
Top pick for Betaine (TMG): BulkSupplements Betaine Anhydrous Powder (1 kg) — 1500g betaine (TMG) per 1 scoop (1.5 g), Third-party tested, cGMP, $0.07/day. Our best-value pick.
Registry check · Betaine (TMG)
Does anyone independently verify Betaine (TMG) supplements?
Not one of these 6 products is listed by NSF, USP or Informed Sport as a verified product. Yet 3 of them advertise “third-party testing” without naming the certifier that did it — wording no public registry can confirm or deny. A factory-level claim such as “cGMP” audits the plant, not the Betaine bottle you would actually receive.
6 checked against all 5,317 US NSF, USP and Informed Sport listings, 2026-08-25. Full method and limitations.
What 6 Betaine labels show
Priced per day, these betaine products run $0.07 to $1.00 — a 14× gap between the cheapest and dearest betaine here, across 5 brands.
All Betaine (TMG) Supplements Compared
| Product | Brand | Dose / Serving | Cost / Day | Certification (as labelled) | Pick | Buy |
|---|---|---|---|---|---|---|
| BulkSupplements Betaine Anhydrous Powder (1 kg) | BulkSupplements | 1500g betaine (TMG) / 1 scoop (1.5 g) | $0.07 | Third-party tested, cGMP | Best Value | Buy |
| Nutricost Betaine Anhydrous TMG Powder (500 g) | Nutricost | 1500g betaine (TMG) / 1 scoop (~1.5 g, unmeasured by label) | $0.08 | 3rd-party tested (ISO lab) | Buy | |
| Vitamatic Betaine Anhydrous (TMG) Powder (250 g) | Vitamatic | 1497g betaine (TMG) / 1 scoop (~1.5 g) | $0.10 | None stated | Buy | |
| Nutricost TMG (Trimethylglycine) 750 mg (120 caps) | Nutricost | 750mg betaine (TMG) / 1 capsule | $0.28 | 3rd-party tested (ISO lab) | Buy | |
| NOW Foods TMG Betaine 1,000 mg (Tablets) | NOW Foods | 1000mg betaine (TMG) / 1 tablet | $0.43 | cGMP (NPA-certified facility) | Buy | |
| Life Extension TMG 500 mg (100 Liquid Veg Caps) | Life Extension | 500mg betaine (TMG) / 1 capsule | $1.00 | GMP; reputable manufacturer | Buy |
Our Picks
Best Value: BulkSupplements Betaine Anhydrous Powder (1 kg)
1500g betaine (TMG) per 1 scoop (1.5 g). Third-party tested, cGMP. $0.07/day. 666 servings per container at $28.97.
The shelf · Betaine
Capsules cost 6.8× what powder does for the same Betaine
The molecule is the same either way; the premium buys encapsulation. Across these 6 Betaine products that gap runs from 7¢ a day (BulkSupplements Betaine Anhydrous Powder (1 kg)) to $1.00 (Life Extension TMG 500 mg (100 Liquid Veg Caps)), and BulkSupplements Betaine Anhydrous Powder (1 kg) is the cheapest powder of the 3 here if you will actually weigh a dose.
Method: the 6 Betaine products above, compared on label facts — serving size, servings per container, form, price. Not a dosing recommendation.
The evidence · Betaine
What the published reviews of Betaine concluded
- Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery. · Nutrients, 2025
“Betaine supplementation modestly improved 60 km cycling performance but had no effect on gut permeability. The metabolomics data supported a strong influence of 2-week intake of betaine on the one-carbon metabolism pathway during the 24 h recovery period.”
- Pilot trials of oral betaine in participants with metabolic dysfunction-associated steatotic liver disease and elevated alanine aminotransferase. · Hepatology (Baltimore, Md.), 2026
“Betaine 8, 4​​​​​​, and 2 g/day for 12-24 weeks significantly reduced ALT and other serologic markers of liver injury among participants with clinically defined MASLD and an elevated ALT.”
- The effects of 14-week betaine supplementation on endocrine markers, body composition and anthropometrics in professional youth soccer players: a double blind, randomized, placebo-controlled trial. · Journal of the International Society of Sports Nutrition, 2021
“Betaine supplementation increased testosterone levels and T/C ratio in youth professional soccer players during a competitive season. Betaine supplementation had no negative effects on growth (height and weight) and may attenuate reductions in testosterone due to intense training during puberty.”
- Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes. · The Journal of clinical endocrinology and metabolism, 2018
“DMG accumulation supports DMG dehydrogenase as rate limiting for betaine metabolism in persons with prediabetes. Betaine had little metabolic effect. Additional studies may elucidate mechanisms contributing to differences between preclinical and human responses to betaine, and whether supplementation of metabolites downstream of DMG improves metabolism.”
Method: PubMed searched in humans for randomised trials with Betaine in the title; these 4 of the 8 that qualified are shown with the authors’ own conclusion quoted rather than summarised. What it cannot tell you: whether Betaine will work for you — each of these reports an average across trials published 2018–2026, and null findings are shown here as readily as positive ones.
How these 6 Betaine (TMG) products were ranked
Not one of these 6 betaine products could be confirmed in the NSF, USP or Informed Sport registries, so verification separates none of them and the ranking falls to cost per day at the labelled serving. Commission does not enter it: the rate is the same whichever betaine you buy. Full methodology.