Vitamin D3 5000 IU with K2: Which Bottles Have Real MK-7
The best vitamin D3 5000 IU with K2 is Nature Made D3 + K2: 5,000 IU of D3 and 100 mcg of K2 as MK-7 in one softgel, and it is the only one we track that is USP Verified. 5,000 IU is above the 4,000 IU daily limit, so take it on a doctor’s advice. If you take warfarin, do not add K2 without your doctor.
By Erin Rose Updated October 18, 2026 How we score
Our pick for: If your doctor says 5,000 IU
- Dose
- 5,000 IU + 100 mcgVitamin D3 and K2 as MK-7
- A day
- $0.42Amazon price
- Bottle
- 30 softgels$12.58, about a month
- Testing list
- USP VerifiedChecked September 22, 2026
- Form
- SoftgelOne a day
- Take
- With a mealOn a doctor’s advice
Why we pick it It is the only 5,000 IU + K2 softgel we track on a testing list. That matters at a high dose: studies that tested vitamin D pills found some far off their labels, from under 10% to about double (Garg 2013). USP Verified checks that the bottle holds what the label says.
What you give up It costs $0.42 a day, about $133 a year more than Horbaach, and comes in a 30-count bottle. See the other picks below.
The best D3 5000 IU with K2 for your needs
Best for the lowest cost: Horbaach D3 + K2
The same 5,000 IU and 100 mcg of MK-7 for $0.05 a day, about $133 a year less than our pick. One bottle of 180 softgels lasts about six months. It is not on a testing list we check.
Horbaach D3 + K2
$0.05 a day · 5,000 IU + 100 mcg MK-7
Best for the K2 dose used in trials: NOW Mega D-3 & MK-7
This capsule has 180 mcg of MK-7, the daily dose tested in a 3-year trial of 244 women after menopause (Knapen 2013). It costs $0.20 a day. It is not on a testing list we check.
NOW Mega D-3 & MK-7
$0.20 a day · 5,000 IU + 180 mcg MK-7
Do you need K2 with vitamin D?
K2 is optional. Vitamin D helps you absorb calcium, and vitamin K turns on proteins that handle calcium (van Ballegooijen 2017). That is why the two are often sold together. But no trial we found has tested D3 with K2 against D3 alone for broken bones or heart problems.
What trials did find is modest. In 8 trials with 971 people, vitamin D with vitamin K raised bone density a little (Kuang 2020). In a 3-year trial, 180 mcg of MK-7 a day slowed bone loss at the spine and the top of the thigh bone in women after menopause, but not at the hip as a whole, and it was not built to show fewer broken bones (Knapen 2013). The full review is in vitamin D with or without K2.
Is 5,000 IU with K2 safe?
5,000 IU is above the 4,000 IU daily upper limit for adults (Ross 2011). Doctors use it for a time to raise a low blood level, then check it again. Adding K2 does not make a higher vitamin D dose safer. Unless your doctor found you low, a 2,000 IU softgel covers most adults. Want D3 with K2 under the limit? Thorne Vitamin D + K2 drops give 2,000 IU a day with K2 and are on NSF/ANSI 173, the best pick for K2 on our best vitamin D page.
If you take warfarin, do not start any K2 product without your doctor. MK-7 at 50 mcg a day or more may interfere with warfarin (Schurgers 2007), and every bottle on this page has at least 100 mcg.
How much K2 to look for on the label
72.5% of the 327 standalone K2 labels we read name MK-7; 22.3% name no form and 4.3% name MK-4. Look for MK-7 with a printed dose. The typical K2 label gives 100 mcg, and the 3-year trial used 180 mcg. Few 5,000 IU bottles add K2 at all: 15.8% of the 95 labels at exactly 5,000 IU that we read in the NIH label database.
5 vitamin D3 + K2 bottles compared
Every bottle here has 5,000 IU of D3 and names its K2 as MK-7. The one on a testing list comes first, then the rest, cheapest per day first at Amazon prices. Buying the cheapest plain 5,000 IU softgel and the cheapest 100 mcg MK-7 we track as two bottles costs $0.09 a day, so a combo is not always the cheaper route.
| Supplement | K2 per softgel | Why it is or is not a pick |
|---|---|---|
| Nature Made D3 + K2$0.42 a day · 30 count | 100 mcg MK-7 | Our pick: USP Verified |
| Horbaach D3 + K2$0.05 a day · 180 count | 100 mcg MK-7 | Lowest cost |
| Micro Ingredients D3 + K2$0.10 a day · 300 count | 100 mcg MK-7 | Not on a testing list we check |
| Nutricost D3 + K2$0.12 a day · 120 count | 100 mcg MK-7 | Not on a testing list we check |
| NOW Mega D-3 & MK-7$0.20 a day · 120 count | 180 mcg MK-7 | 180 mcg, the trial dose |
Questions people ask
Do I need K2 with 5,000 IU of vitamin D3?
No trial shows you do. No trial we found has tested D3 with K2 against D3 alone for broken bones or heart problems. Pooled trials of vitamin D with vitamin K found a small gain in bone density (Kuang 2020). Take the combo if you want K2 anyway. Vitamin D with or without K2.
How much MK-7 should a D3 + K2 softgel have?
Look for a printed dose of MK-7. The typical standalone K2 label gives 100 mcg, and a 3-year trial used 180 mcg a day (Knapen 2013). Every bottle on this page has 100 or 180 mcg. If a label says “with K2” but gives no dose or form, you cannot tell what you are getting.
MK-7 or MK-4 in a vitamin D3 + K2 combo?
MK-7. It lasts longer in the blood, so daily doses build up (Schurgers 2007). In a small study, MK-7 raised blood K2 levels, while MK-4 at the doses tested did not (Sato 2012).
Which vitamin D3 5000 IU with K2 is best?
Nature Made D3 + K2, because it is the only one we track on a testing list (USP Verified). Horbaach D3 + K2 costs the least, and NOW Mega D-3 & MK-7 has the 180 mcg trial dose of K2.
Is 5,000 IU of vitamin D3 too much, with or without K2?
It is above the 4,000 IU daily upper limit for adults, so take it on a doctor’s advice, usually to fix a low blood level. K2 does not make 5,000 IU safer. Vitamin D side effects.
Can I take a D3 + K2 combo on warfarin?
Not without your doctor. MK-7 at 50 mcg a day or more may interfere with warfarin (Schurgers 2007), and every bottle here has at least 100 mcg. Vitamin K and warfarin.
More on vitamin D
Best vitamin D supplement, best vitamin D3 K2 supplement at an everyday dose, 1,000 vs 5,000 IU, vitamin D with or without K2, vitamin D side effects and vitamin K.
How we picked
We compared every 5,000 IU D3 + K2 product we track. We checked USP Verified, NSF/ANSI 173, NSF Certified for Sport, Informed Sport and Informed Choice for each on September 22, 2026, and priced each on Amazon on November 6, 2026. We read each bottle’s K2 dose from its Amazon listing or its NIH label. The label data is free to reuse: download it. Our method.
Sources
- Knapen MH, et al. “Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.” Osteoporos Int. 2013. PubMed 23525894
- Kuang X, et al. “The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials.” Food Funct. 2020. PubMed 32219282
- Schurgers LJ, et al. “Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.” Blood. 2007. PubMed 17158229
- Garg S, et al. “Evaluation of vitamin D medicines and dietary supplements and the physicochemical analysis of selected formulations.” J Nutr Health Aging. 2013. PubMed 23364495
- Sato T, et al. “Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women.” Nutr J. 2012. PubMed 23140417
- van Ballegooijen AJ, et al. “The synergistic interplay between vitamins D and K for bone and cardiovascular health: a narrative review.” Int J Endocrinol. 2017. PubMed 29138634
- Ross AC, et al. “The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know.” J Clin Endocrinol Metab. 2011. PubMed 21118827
- Testing lists, read September 22, 2026: USP Verified, NSF/ANSI 173, NSF Certified for Sport, Informed Sport and Informed Choice. Labels: NIH Office of Dietary Supplements, Dietary Supplement Label Database (dsld.od.nih.gov).