{
  "name": "Seed DS-01 Alternatives: Named-Strain Probiotics by Cost per Day",
  "license": "https://creativecommons.org/licenses/by/4.0/",
  "attribution": "Verified Supplement Data, https://verifiedsupplementdata.com/probiotics/seed-alternatives/",
  "dateModified": "2026-10-19",
  "methodology": "Strain, count and serving are as each product label or listing states them; cost per day is the brand's own list price divided by servings at the label serving (costBasis says when an Amazon price is used instead). The evidence tier is the strongest study verified on PubMed for that exact strain. Seed's strain list is not reproduced because it appears on neither its Amazon listing nor an NIH DSLD label. Census figures were recomputed in two halves split by label-id parity within each population; figures that did not agree within tolerance are not published.",
  "benchmark": {
    "name": "Seed DS-01 Daily Synbiotic (53.6B AFU, 60ct)",
    "brand": "Seed",
    "slug": "seed-ds01-daily-synbiotic",
    "strainNamedOnLabel": "24 strains, not named on the Amazon listing; not filed with the NIH DSLD",
    "countPerServing": "53.6 billion AFU",
    "servingSize": "2 capsules",
    "servingsPerContainer": 30,
    "priceUsd": 59.99,
    "priceVerifiedOn": "2026-11-06",
    "costPerDayUsd": 2,
    "costBasis": "brand list price",
    "evidenceTier": "Brand trial, not on file",
    "outcomeTested": "brand says its full formula was tested in its own trials; not verified here",
    "evidenceSource": "seed.com",
    "certification": "None",
    "nihDsldId": null,
    "availability": "ok",
    "note": "AFU (active fluorescent units) is a flow-cytometry viable-cell count, not CFU"
  },
  "alternatives": [
    {
      "name": "Schiff Digestive Advantage Daily Probiotic (2B CFU BC30, 80ct)",
      "brand": "Schiff",
      "slug": "schiff-digestive-advantage",
      "strainNamedOnLabel": "Bacillus coagulans GBI-30, 6086",
      "countPerServing": "2 billion CFU",
      "servingSize": "1 capsule",
      "servingsPerContainer": 80,
      "priceUsd": 24,
      "priceVerifiedOn": "2026-11-06",
      "costPerDayUsd": 0.357,
      "costBasis": "brand list price",
      "evidenceTier": "Preliminary RCT",
      "outcomeTested": "IBS pain and bloating, 44 patients, within-group analysis",
      "evidenceSource": "Hun 2009, PMID 19332970",
      "certification": "None",
      "nihDsldId": null,
      "availability": "ok"
    },
    {
      "name": "Culturelle Daily Probiotic (10B CFU, 30ct)",
      "brand": "Culturelle",
      "slug": "culturelle-daily-probiotic",
      "strainNamedOnLabel": "Lactobacillus rhamnosus GG",
      "countPerServing": "10 billion CFU",
      "servingSize": "1 capsule",
      "servingsPerContainer": 30,
      "priceUsd": 17.47,
      "priceVerifiedOn": "2026-11-06",
      "costPerDayUsd": 0.6,
      "costBasis": "brand list price",
      "evidenceTier": "Cochrane / meta-analysis",
      "outcomeTested": "antibiotic-associated diarrhea, 8% vs 19% across 23 pediatric trials (RR 0.46); adults+children RR 0.58, NNT 13",
      "evidenceSource": "Goldenberg 2015, PMID 26695080; Hempel 2012, PMID 22570464",
      "certification": "None",
      "nihDsldId": null,
      "availability": "ok"
    },
    {
      "name": "RepHresh Pro-B Vaginal Probiotic (5B CFU GR-1/RC-14, 30ct)",
      "brand": "RepHresh",
      "slug": "rephresh-pro-b",
      "strainNamedOnLabel": "L. rhamnosus GR-1 + L. reuteri RC-14",
      "countPerServing": "5 billion CFU",
      "servingSize": "1 capsule",
      "servingsPerContainer": 30,
      "priceUsd": 23.09,
      "priceVerifiedOn": "2026-11-06",
      "costPerDayUsd": 0.883,
      "costBasis": "brand list price",
      "evidenceTier": "RCTs",
      "outcomeTested": "vaginal flora restored in 37% vs 13% (64 women); newer trials found less",
      "evidenceSource": "Reid 2003, PMID 12628548; Husain 2020, PMID 30932317",
      "certification": "None",
      "nihDsldId": null,
      "availability": "ok"
    },
    {
      "name": "Align Probiotic (1B CFU B. infantis 35624, 28ct)",
      "brand": "Align",
      "slug": "align-probiotic",
      "strainNamedOnLabel": "Bifidobacterium longum 35624 (B. infantis 35624)",
      "countPerServing": "1 billion CFU",
      "servingSize": "1 capsule",
      "servingsPerContainer": 28,
      "priceUsd": 26.86,
      "priceVerifiedOn": "2026-11-06",
      "costPerDayUsd": 1.08,
      "costBasis": "brand list price",
      "evidenceTier": "Large RCT",
      "outcomeTested": "IBS pain, bloating and gas at 1e8 CFU/day over 4 weeks (362 women); 1e10 no better than placebo",
      "evidenceSource": "Whorwell 2006, PMID 16863564",
      "certification": "None",
      "nihDsldId": null,
      "availability": "ok"
    },
    {
      "name": "Visbiome High Potency Probiotic (112.5B CFU, 60ct)",
      "brand": "Visbiome",
      "slug": "visbiome-high-potency",
      "strainNamedOnLabel": "De Simone formulation (8 strains)",
      "countPerServing": "112.5 billion CFU",
      "servingSize": "1 capsule",
      "servingsPerContainer": 60,
      "priceUsd": 73.95,
      "priceVerifiedOn": "2026-11-06",
      "costPerDayUsd": 1.216,
      "costBasis": "brand list price",
      "evidenceTier": "Large RCT + guideline",
      "outcomeTested": "ulcerative colitis, add-on to standard treatment, 63.1% vs 40.8% response (144 patients)",
      "evidenceSource": "Tursi 2010, PMID 20517305",
      "certification": "None",
      "nihDsldId": null,
      "availability": "ok"
    },
    {
      "name": "Florastor Daily Probiotic (250mg S. boulardii, 30ct)",
      "brand": "Florastor",
      "slug": "florastor-daily-probiotic",
      "strainNamedOnLabel": "Saccharomyces boulardii CNCM I-745",
      "countPerServing": "250 mg",
      "servingSize": "2 capsules (500 mg S. boulardii)",
      "servingsPerContainer": 15,
      "priceUsd": 27.59,
      "priceVerifiedOn": "2026-11-06",
      "costPerDayUsd": 1.931,
      "costBasis": "brand list price",
      "evidenceTier": "Cochrane / meta-analysis",
      "outcomeTested": "antibiotic-associated diarrhea 18.7% to 8.5% across 21 trials (RR 0.47, NNT 10); traveler's diarrhea RR 0.79",
      "evidenceSource": "Szajewska 2015, PMID 26216624; McFarland 2019, PMID 30278238",
      "certification": "None",
      "nihDsldId": null,
      "availability": "ok"
    }
  ],
  "notRanked": [],
  "labelCensus": {
    "source": "NIH Dietary Supplement Label Database (DSLD) v9",
    "sourceUrl": "https://dsld.od.nih.gov/",
    "retrievedOn": "2026-09-16",
    "labelsRetrieved": 900,
    "labelsAnalysed": 896,
    "generalLabels": 819,
    "womenMarketedLabels": 77,
    "general": {
      "structuredCfuQuantityPct": 8.8,
      "medianSpeciesNamed": 5,
      "namingLCrispatusPct": 0.5
    },
    "women": {
      "proprietaryBlendRowPct": 93.5,
      "namingGr1Rc14Pct": 14.3,
      "namingLCrispatusPct": 2.6
    },
    "validation": {
      "method": "split-half by DSLD id parity within population",
      "checked": 9,
      "held": 6,
      "failed": [
        "women's labels with a structured CFU quantity",
        "women's labels adding cranberry / D-mannose",
        "median species named, women's labels"
      ]
    },
    "notPublished": [
      "women's labels with a structured CFU quantity",
      "women's labels adding cranberry / D-mannose",
      "median species named, women's labels",
      "share of general labels naming L. rhamnosus GG (computed, not split-half checked)"
    ]
  }
}